The extraction of useful knowledge from voluminous data produced
by high-throughput genomics presents a significant challenge to the scientific community.
Efficient mining of this data for the needs of biomedical research critically depends
on seamless integration of clinical, genomic and experimental information with prior
knowledge about genotype-phenotype relationships accumulated in a plethora of publicly
available databases. Furthermore, such experimental data should be accessible to a
variety of algorithms and analytical pipelines that drive computational analysis and
data mining. To address these challenges we are developing Lynx -- a scalable computational
platform based on cross-cutting requirements from multiple scientific groups for data
integration, management and analysis. The goal of Lynx is to provide an end-to-end support
for the analytical needs of various translational projects.
My major scientific interest is the development of the approaches for representation and analysis of complex biological systems and how these approaches can be applied to the discovery of the molecular mechanisms contributing to complex heritable disorders.
Director, Clinical and Translational Research Informatics
Duchossois Family Institute (DFI), BSDPostdoctoral Researcher
Application Developer
Bioinformatics Researcher
j3xu@tti-c.org
wangsheng@ttic.edu
ildubchak@lbl.gov
Alex_Paciorkowski@urmc.rochester.edu
gmirzaa@uw.edu
hashemifar@ttic.edu
wangsheng@ttic.edu